Hardknott/Wrynose is incredible to do on a bike but it can be daunting, when you have extremely tight little hairpins double-backing at very steep gradients. If you do take a chance with those (and I can't see why a Pan Euro can't do it), be sure not to stall when you're taking the turn. Drop it there, and you and the bike will probably fall quite a long way! And it would be painful. Keep the revs up and you should be fine.
I strongly recommend a circuit taking in the Kirkstone Pass (A592), the A686 Penrith-Alston road, A689 Alston to Stanhope (with a visit to the "Killhope" Lead Mine, fascinating), B6278 Althorp to Middleton on Tees, B6276 to Brough, then A685 then A683 to Sedbergh.
Also, if you are in the area, take the A595 Ravenglass to Barrow, that road is just built for bikes. As is the A161 that goes due south from Goole, East Yorkshire - should you choose to ride across the Pennines and take an eastern southbound route home, as we did.